Fixed Dose Procedure

The fixed-dose procedure (FDP) was proposed in 1984 to test a substance's acute oral toxicity using fewer animals with less suffering than the older LD50 test w…

The fixed-dose procedure (FDP) was proposed in 1984 to test a substance's acute oral toxicity using fewer animals with less suffering than the older LD50 test which was developed in 1927.

FDP uses 10-20 animals to find the dose that produces toxicity signs but not death, and from there predicts the lethal dose. LD50 ("lethal dose 50%") uses 60-80 animals to find a dose that kills 50% of animals in a given time. FDP sometimes needs retesting using slightly higher or lower doses.

Other websites


Content Disclaimer

Informasi ini disarikan dari Wikipedia dan disajikan kembali untuk tujuan edukasi. Konten tersedia di bawah lisensi CC BY-SA 3.0. Kami tidak bertanggung jawab atas ketidakakuratan data yang bersumber dari kontribusi publik tersebut.

  1. The information displayed on this website is sourced in part or in whole from Wikipedia and has been adapted for the purpose of restating it. We strive to provide accurate and relevant information, however:
  2. There is no guarantee of absolute accuracy. Wikipedia is an open, collaborative project that can be edited by anyone, so information is subject to change.
  3. It is not intended to constitute professional advice. The content displayed is for informational and educational purposes only. For important decisions (e.g., medical, legal, or financial), please consult a professional.
  4. Content copyright. Wikipedia is licensed under the Creative Commons Attribution-ShareAlike License (CC BY-SA). This means that content may be reused with appropriate attribution and shared under a similar license.
  5. Responsible use. Any risk arising from the use of information from this website is entirely the responsibility of the user.